TECH OFFER

Synthetic Biology Biosensor (CYCsensor) for the Discovery of Quorum Sensing Inhibitors

TECHNOLOGY OVERVIEW

The present invention generally relates to a synthetic biology biosensor (Cycsensor) for discovery of quorum sensing inhibitors. Accordingly, the synthetic biology biosensor (Cycsensor) for discovery of quorum sensing inhibitors, the Cycsensor includes: a) araC gene encoding for AraC repressor protein for repressing expression of signal synthase gene driven from PBAD promoter, wherein inducible promoter PBAD drives downstream gene expression in presence of arabinose; b) representative rhlI from Pseudomonas aeruginosa for C4-HSL production, wherein the representative rhlI is driven by PBAD promoter in presence of arabinose; c) representative rhlR from Pseudomonas aeruginosa for responding to C4-HSL, wherein the representative rhlR is driven from a constitutive promoter; and d) representative green fluorescent protein gene, gfp, wherein the representative green fluorescent protein gene, gfp is expressed from the responding Prhl promoter which is only functional in presence of RhlR/C4-HSL complex.

Mega - Trends

Healthcare

Technology Readiness Level (TRL)

TRL 3

Patent Number

PI 2016703909

Get the technology fact sheet here:

Contact person for this offer:

ChM Dr. Lee Ching Shya, PhD (Dual), RTTP

Technology Transfer Manager

Email: leecs@um.edu.my

Tel: +603-7967-7351/ 013-2250151

MAKE AN ENQUIRY

press to zoom

press to zoom
1/1

MORE INFORMATION

You have a question to know about technologies or cooperations? 
Please Contact Us:

+603 - 7967 7351 / 013-2250151